Sleep Apnoea


Obstructive sleep apnoea (OSA) is now recognized to be an independent risk factor for daytime hypertension. Much data suggest that OSA is a cardiovascular disease risk factor for stroke, coronary artery disease or heart failure. A prevalence of 4% has been reported in the general population. The prevalence raises to much higher level in patients with cardiovascular diseases (50% in patients with hypertension, 30% in patients with Acute coronary syndromes, 60% in patient with stroke).

Nevertheless, most of individuals with OSA are asymptomatic for their apnea and remain undiagnosed, presenting instead hypertension, arrhythmia or congestive heart failure.

Polysomnography is the gold standard diagnostic tool for assessing sleep-disordered breathing. It requires an overnight stay in a sleep laboratory but several months waiting list are commonly observed to have access to this procedure.

HolterSoft Ultima is a simple and effective software allowing for the first time the cardiologists to massively screen their patients for OSA. NOVACOR's ground breaking solution is based on a single index (% VLFI) derived from a simple ECG Holter procedure.

%VLFI is derived from the analysis of the RR variability and thus quantifies the abnormal parasympathetic and sympathetic regulations associated to each apneic event.

The efficiency of the %VLFI and the interest in clinical routine have been established by several scientific publications.

Use of high-frequency peak in spectral analysis of heart rate increment to improve screening of obstructive sleep apnoea .

Use of thoracic impedance sensors to screen for sleep-disordered breathing in patients with cardiovascular disease .

Cardiac Variability and Heart-Rate Increment as a Marker of Sleep Fragmentation in Patients With a Sleep Disorder - a Preliminary Study

The use of heart rate variability in detecting sleep disordered breathing in patients with heart failure

Screening of obstructive sleep apnea syndrome by heart rate variability analysis

Cardiac interbeat interval increment for the identification of obstructive sleep apnea.

The unexpected sleep apnea syndrome is highly prevalent and associated with the alteration of the autonomic nervous system activity in a general 65 years old population. The PROOF study

Heart rate increment- an electrocardiological approach for the early detection of obstructive sleep apnoea-hypopnea syndrome

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